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Emotion dysregulation as a transdiagnostic mechanism of opioid misuse and suicidality among chronic pain patients

Chronic pain is a prevalent condition that causes functional impairment and emotional suffering. To allay pain-induced suffering, opioids are often prescribed for chronic pain management. Yet, chronic pain patients on opioid therapy are at heightened risk for opioid misuse—behaviors that can lead to addiction and overdose. Relatedly, chronic pain patients are at elevated risk for suicidal ideation and suicidal behaviors.

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Prescription opioid misusing chronic pain patients exhibit dysregulated context-dependent associations: Investigating associative learning in addiction with the cue-primed reactivity task

In this study, the authors utilized a novel psychophysiological probe of pain-opioid conditioned associations, the cue-primed reactivity (CPR) task, to assess associative learning and second-order conditioning effects among chronic pain patients taking long-term opioid analgesics.

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Last Updated: 12/12/23