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Prescription opioid misusing chronic pain patients exhibit dysregulated context-dependent associations: Investigating associative learning in addiction with the cue-primed reactivity task

In this study, the authors utilized a novel psychophysiological probe of pain-opioid conditioned associations, the cue-primed reactivity (CPR) task, to assess associative learning and second-order conditioning effects among chronic pain patients taking long-term opioid analgesics.

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Enhancing natural reward responsiveness among opioid users predicts relief from chronic pain: An analysis of EEG data from a trial of Mindfulness-Oriented Recovery Enhancement.

Although opioid-treated chronic pain patients evidence blunted responsiveness to natural rewards, focusing on naturally rewarding stimuli can produce analgesia in these patients. A prior randomized controlled trial (RCT) demonstrated that a social work intervention—Mindfulness-Oriented Recovery Enhancement (MORE)...

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Mindfulness-oriented recovery enhancement for chronic pain and prescription opioid misuse: Results from an early-stage randomized controlled trial

Opioid pharmacotherapy is now the leading treatment for chronic pain, a problem that affects nearly one third of the U.S. population. Given the dramatic rise in prescription opioid misuse and opioid-related mortality, novel behavioral interventions are needed. The purpose of this study was to conduct an early-stage randomized controlled trial of Mindfulness-Oriented Recovery Enhancement (MORE), a multimodal intervention designed to simultaneously target mechanisms underpinning chronic pain and opioid misuse.

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Last Updated: 4/14/21